Pharmacogenetics

FDA Approved Pharmacogenetics Tests Helping Physicians
with Superior Clinical Management of Patients

  • Why test?

    Total prescription demand increased in 2015 to 4.4Bn1 with 50-75% not working as intended2 Every year, more than 8.6 million adverse drug events (ADEs) are reported in the U.S., 2.2 million of them are severe causing 700,000+ deaths and 120,000+ hospitalizations. In fact, ADEs are the fourth leading cause of death Nationwide3, after heart disease, cancer and stroke, and they place an enormous financial burden on the healthcare system. Even with proper prescribing, a patient’s genes can affect how they metabolize and respond to drugs. More than 85% of patients have detectable variations in their DNA that affect their response to drugs and increase their risk for an ADEs 4,5.

  • Advantages of Genesys Diagnostics Inc Personalized Medicine Test

    By identifying which inherited genetic variations a patient has will

    • Improve patient outcomes when initiating drug regimens
    • Result in no more trial and error dosing
    • Reduce risk of harmful drug-to-drug interactions
    • Reduce risk of adverse drug events (ADEs)
    • Save healthcare costs an estimated $3.5 billion


 Who is this test useful for?

Anyone can take the test, however, this test offers clinicians the ability to personalize drug therapy and increase safety and compliance in the most challenging cases such as

  • Patients experiencing drug intolerance, side effects, treatment resistance or therapeutic failure to medications
  • Patients treated with multi-drug combinations
  • Children, adolescents, the elderly and the infirm
  • Patients hospitalized or with multiple medical conditions


 Our Answer

Giving physicians the necessary tools to select the proper drug therapy for their patients, at the proper dose, while avoiding unnecessary side effects.



 Personalized Health Reports

Provides clinicians access to information for gene-guided prescription drugs widely used in medicine:

  • Neuro-Psychiatric Drugs: antidepressants, pain, antipsychotics, Stimulants, addiction, anticonvulsants, neurodegenerative, anxiolytics, sleep
  • Cardio-Metabolic Drugs: hypertension, cholesterol, diabetes, gastric reflux, asthma, erectile dysfunction, angina, antithrombotics, heart failure
  • Pain Drugs: enables diagnosis and management of pain management drugs and the efficacy for patients.

 Results interpretation with a MEDreview Report

Medreview is a genetic assessment of the medicines currently prescribed or being considered for the patient. Medreview provides an easy to comprehend report immediately identifying areas of concern for the physician specific to the patient’s medication list and their pharmacogenetics disposition. Appropriate alternative therapies are identified, dosing guidance and drug/drug interactions provided.
Medreview is used for patients on multi-drug regimens for the common diseases in general medicine and mental health: blood pressure, cholesterol, heart attacks, depression, diabetes, asthma, heartburn,inflammation, blood clots, pain management, acid reflux, sexual dysfunction, addiction, diabetes, and sleep.

 Potentially Impacted Medications

Category Drug Use as Directed Use with Caution Consider Alternatives Drug Interactions
5 Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia Dutasteride
Finasteride
Alpha-Blockers for Benign Prostatic Hyperplasia Alfuzosin ! Fluconazole
Duxazosin
Silodosin
Tamsulosin
Terazosin
Angiotensin II Receptor Antagonists Irbesartan !! Bactrim
Antiaddictives Bupropion ! ! Bupropion
!! Rifadin

 How It Works

STEP1 Clinician orders the Genesys Pharmacogenomics Test for patient
STEP2 Clinician conducts the Test in office and FedEx Pre-paid to Lab
STEP3 Genesys processes the sample and sends Pharmacogenomics Test Report to Clinician


 Multiple Panels & 16 genes being tested?

Medical Management Panel: (CYP1A2, CYP2B6, CYP2C19, CYP2D6, CYP2C9, VKORC1, CYP3A4, CYP3A5, OPRM1, COMT, ANKK1/DRD2, Factor II, Factor V, MTHFR, APOE, SLCO1B1)
Psychiatry Panel: (CYP1A2, CYP2D6, CYP2C19, CYP2C9, CYP3A4, CYP3A5, COMT, ANKK1/DRD2)
Pain Management Panel: (CYP1A2, CYP2D6, CYP2C19, CYP3A4, CYP3A5, CYP2B6, CYP2C9, OPRM1, Factor II, Factor V, MTHFR)
Neurology Panel: (CYP1A2, CYP2B6, CYP2C19, CYP2D6, CYP2C9, COMT, OPRM1)
Cardiovascular Panel: (CYP2C19, CYP2D6, CYP2C9, VKORC1, CYP3A4, CYP3A5, Factor II, Factor V, MTHFR, APOE, SLCO1B1)
Orthopedic Panel: (CYP2D6, CYP2C19, VKORC1, CYP3A4, CYP3A5, Factor II, Factor V, MTHFR)
Gastrointestinal Panel: (CYP2D6, CYP2C19)
Urological Panel: (CYP2D6)

 Test information

Description Genesys Diagnostics Inc. Pharmacogenetics
Method Multiplex Bead Array
Specimen Requirements Buccal Swab
Turnaround Time 5-7 Days
Shipping Pickup/Fedex Service Available Monday – Friday
Testing Performed Monday-Saturday

 How Genesys can help

  • Our online portal provides results instantaneously
  • Our LIS integration with EMRs simplifies results availability and frees up time for your clinic
PAYMENT OPTIONS: Insurance or Self Pay

Customer Service: Dedicated experts are available to answer your questions. Speak with a clinical specialist, pharmacist or client specialist, pharmacist, or client service representative.